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Discount Pet Medications => : Flea & Tick :: Comfortis :

Start => : Flea & Tick :: Comfortis :


This product is being discontinued by the manufacturer.  Customers are advised to switch to their newer product line, Credelio which also kill major types of ticks. To include the heartworm preventions, we also advice Nexgard Spectral for the same plus ticks protections.

Customers are recommended to order the new product.

Comfortis is the first approved chewable tablet that kills fleas and prevents flea infestations on dogs and cats for a full month. Only Comfortis offers you all of these benefits in a single product: Starts killing fleas within 30 minutes. Lasts a full month. Kills fleas before they can lay eggs. The convenience of a chewable, synthetic beef-flavored tablet. Spinosad, the active ingredient in Comfortis, is environmentally friendly.

For: Dogs and Cats 14 weeks of age or older


  • Starts killing fleas within 30 minutes
  • Lasts a full month
  • Kills fleas before they can lay eggs
  • Comes in a convenient chewable, beef-flavored tablet
  • Spinosad, the active ingredient in Comfortis, is environmentally friendly

Spinosad kills fleas by causing excitation of the insect's nervous system, leading to paralysis and rapid death.

Side effects may occur, including vomiting. If your pet is experiencing loss of appetite, lethargy, or any other difference in behavior, contact your veterinarian. The FDA has received reports of adverse reactions in dogs receiving the drug Comfortis (spinosad) concurrently with high, extra-label doses of ivermectin. Dogs receiving extra-label doses of ivermectin to treat non-responsive demodectic mange and other conditions have developed signs of ivermectin toxicity.

Manufacturer: Elanco Animal Health


Comfortis tablets are administered orally at a recommended dose of 45-70mg/kg bodyweight for dogs, and 50-75 mg/kg for cats.

Color Pet Weight (lb) Weight (kg) Spinosad (mg)
Mauve Small Cats 2.6 - 4.0 lbs 1.2 - 1.8 kg 90 mg
Mauve Puppies 2.8 - 4.4 lbs 1.3 - 2.0 kg 90 mg
Yellow Medium Cats 4.2 - 6.2 lbs 1.9 - 2.8 kg 140 mg
Pink Ex Small Dogs 5 - 10 lbs 2.3 - 4.5 kg 140 mg
Orange Large Cats 8.1 - 11.9 lbs 3.7 - 5.4 kg 270 mg
Orange Small Dogs 10.1 - 20 lbs 4.6 - 9 kg 270 mg
Green Medium Dogs 20.1 - 40 lbs 9.1 - 18 kg 560 mg
Blue Large Dogs 40.1 - 60 lbs 18.1 - 27 kg 810 mg
Brown Ex Large Dogs 60.1 - 120 lbs 27.1 - 54 kg 1620 mg

More Information

Brand Name: Comfortis

Generic Name: Spinosad

Comfortis is a chewable, synthetic beef flavored tablet (derived from pork protein and hydrolyzed soy) that is given to the dog to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are for monthly use in dogs and puppies 14 weeks of age and older.

What should I discuss with my veterinarian before giving Comfortis to my pet:
Tell your veterinarian if you are planning on breeding your pet. Tell your veterinarian if your dog has a history of seizures (epilepsy).

How should this medication be given:
Give Comfortis chewable tablets with food. Give Comfortis chewable tablets once a month. Comfortis chewable tablets may be chewed, offered in food, or administered like other tablet medications. If vomiting occurs within 1 hour of administration, redose the pet with another full dose. Store Comfortis at room temperature (68-77??)

What happens if I miss a dose:
Give the missed dose with food as soon as you remember and resume a monthly dosing schedule.

What happens if I overdose the pet:
Overdose of this medication is unlikely. However, if an overdose is suspected, contact your veterinarian or veterinary emergency room. Symptoms of overdose that may occur include vomiting.

What should I avoid while giving Comfortis:
Your pet may maintain normal activities and interactions while being given Comfortis. The safe use of Comfortis chewable tablets in male dogs intended for breeding has not been established.

What are the possible side effects of Comfortis:
Side effects that may occur include vomiting. If vomiting occurs within one hour of administration, redose with another full dose. Other side effects may occur. Continue giving Comfortis chewable tablets and talk to your veterinarian if your pet experiences decreased appetite, lethargy or decreased activity, diarrhea, cough, increased thirst, vocalization, increased appetite, redness of the skin, hyperactivity and excessive salivation. Talk to your veterinarian about any side effect that seems unusual or especially bothersome to the pet.

What other drugs will affect Comfortis:
Talk to your veterinarian before giving any prescription or over the counter medications.

Where can I get more information:
Your pharmacist has additional information about Comfortis written for health professionals that you may read.


Comforits works great on my lab mixed dog. The only problem with it is that the pill is too big. I have to break it up into 2 or 3 pieces and give it to him thru out the day, otherwise he gets sick and vomits not long after I give him the pill. It helps to give him the small portions with something to eat. I almost stopped using it, but it really keeps the fleas away.

I moved from place where the climate changes to a place where the fleas never die. My Pom Sasha never had trouble with fleas and i never had to use anything to keep them off of her. We moved down south and oh my gosh she has been infested with them and nothing works. I used this flea pill and wow to my surprise 30-40 minutes later the fleas were just dropping off of her dead. It was worth every penny I paid for it.

The topical solutions are not solutions at all - none have worked for either my cat or dog. I have been using Comfortis for the past 3 years and I am extremely pleased with the results. If you want something that is effective, this is it. It is more expensive than the topical products, but if the topical products don't work, why buy them?! I highly recommend Comfortis and will continue to use it in both of my animals.

I took my dog to my vet for itching . He gave me this tablet to give to him and within 30 mintues I found little dead fleas all over his coat. One tablet last for a month so the price is worth it. Im looking to buy it more then the droplets and flea collars which are not as effective as this tablet. I do must say one side effect it cause is itching extremely but it is because of the dead fleas not an allergic reaction. So if ur dog itches afterward it is ok it means the product is working like it should.

My Shar-pei/Lab mix has flea allergies, but what dog doesn't? Comfortis is strong on her stomach so I have to be sure she eats well before I give it to her. She doesn't scratch anymore while taking comfortis and I notice her coat and skin seem to look much better! They say the tabs are chewable but she won't touch it due to the high chemical smell of the tablet. I wrap cheese around it and she swallows it whole ;) . I cannot give this medication to her along with a heartworm medicine because it makes her nauseous so I space them apart by a week or so. She has been on this for over a year and I am very pleased!

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