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Discount Pet Medications => : Heartworm Preventatives :: Simparica :Start => : Heartworm Preventatives :: Simparica :
Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more.
Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines. Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite. Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.
Active Ingredient : Sarolaner, Moxidectin, Pyrantel (as pamoate salt)
Give your dog one chewable monthly, with or without food. Follow your veterinarian's instructions exactly as directed. The recommended minimum dose is 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 ??/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).
In case your dog is like my two who only will eat chews and that??s if they taste like actual chicken which is a pain because most of the time nothing ever does this is an actual tablet/pill that my pickiest dog actually sat down and chewed right up and swallowed. This is so far perfect!
Considering it's one pill for everything - easier than multi dosing. Our Shih Tzu won't eat it, so we wrap it in cheese. That works.
We live in western North Carolina where it rains ticks. This is the only thing that works. We tried topicals and flea and tick collars and the are useless. It is very expensive, but with the Pet Meds discount and an additional $25 manufacturers vet rebate on the next visit I think I can get the six month cost down to $105 for a 30 lbs dog. The first package purchased from the office cost $155. I previously used Sentinel Plus that has no tick protection and is marginal for fleas. If ticks aren??t your problem you can get something else for a third the cost. Subtracted one star for cost.
It works!!! I stay with my mom..she has 2 dogs of her own. Her 2 dogs had a major flea problem (her two were not using this product) while mine managed to stay flea & tick free on this product!!